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GLP-1RAs have reliable hypoglycaemic and weight-loss effects that can intervene in obesitythe basis of type 2 diabetes pathologyand multifaceted effects on other cardiometabolic parameters, such as blood pressure and circulating lipids [21]

First, weight loss is a reproducible finding over a 36-months window, and in many cohorts the mean reduction reaches ranges commonly considered clinically meaningful for reproductive planning (often cited around 5% of baseline weight), with some studies reporting larger decreases

PMID 16330153

Most of it is in the neurons of the brain in an area called the raphe nucleus of the brain