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mTOR regulates phosphorylation of p70 S6 kinase (p70S6K) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), the two best-characterized downstream effector molecules of mTOR 10

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In addition to their anti-hyperglycaemic effects, these agents have been associated with CV protection in two large CV outcome trials [8, 9]

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