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Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite, Trimethylamine-N-oxide, in Patients with Heart Failure: Refining the Gut Hypothesis

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Reduced GSH levels shown by decreases in this ratioboth in the plasma and intracellularlyreflect intracellular shifts in oxidative burden and are indicative of immune dysfunction and progression of various disease states such as infection, sepsis, and age-related immune system decline (Rossi et al., 2006