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Bariatric surgery carries the risk of various complications, including nutritional deficiencies, which necessitate thorough discussions before deciding on surgery

Methods Protocol The study protocol for the present systematic review was first published 23 January 2021 in the PROSPERO database, Protocol deviations The following deviations from the initial protocol were necessary and were amended in a protocol update: the search strategy was updated to include Embase and Cochrane

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Exogenous administration of protease-resistant, non-matrix-binding IGFBP-2 inhibits tumour growth in a murine model of breast cancer