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A phase 2, randomized, double-blind, placebo-controlled study of senolytic molecule UBX0101 in the treatment of painful knee osteoarthritis
Limited Western clinical data exists, but available evidence from Phase II trials in anxiety and cognitive dysfunction shows tolerability comparable to placebo with BDNF expression increases of 150-300% in hippocampal tissue
Safety and Toxicity: The safety of senolytic and senomorphic therapies is one of the foremost concerns in clinical translation
(December 2005)
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