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Overview of Clinical Trial Study 1 (NCT03574597) was a multi-national, multi-center, placebo-controlled, double-blind trial to determine the effect of WEGOVY relative to placebo on major adverse cardiovascular events (MACE) when added to current standard of care, which included management of CV risk factors and individualized healthy lifestyle counseling (including diet and physical activity)

In his statement announcing the FDAs approval of leucovorin, Makary said that the agency had reached this decision after a systematic analysis of literature published between 2009-2024

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