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Under glucose-deprived conditions, the knockout of IDH1 or ME1 significantly reduces the NADPH/NADP+ and GSH/oxidized GSH ratios, leading to elevated ROS levels and increased cell death in cancer cells (94)

The clinical evidence exists but is limited small trials, older studies, no large RCTs

CJC-1295 has reached phase 2 trials, but development was discontinued following a fatal myocardial infarction in a participant shortly after their 11th dose of CJC-1295 [8, 9]