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Enhancing GABA inhibition could alleviate depression, anxiety, and chronic pain in patients with IBS ( Vitamins The intestinal microbiota actively affects the one-carbon metabolism and the utilization of vitamins, especially vitamin D and B6 (pyridoxine), in IBS patients (Ligaarden and Farup, 2011)

The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages

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Moderate amounts, perhaps 150 to 200 minutes of low-to-moderate intensity cardio weekly, complement strength training without interfering with recovery