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Lysosomal stress response (LSR): physiological importance and pathological relevance

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FGF21 is produced primarily in the liver in response to metabolic stress and acts as a systemic regulator of energy balance stimulating fatty acid oxidation, promoting adiponectin secretion, and supporting healthy mitochondrial function in brown adipose tissue.* FGF21 levels are closely correlated with metabolic flexibility the ability of cells to switch efficiently between fuel sources