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We further observed that r-sFNDC5 stimulated the expression of key genes involved in fatty acid -oxidation (PPAR), mitochondrial biogenesis (PGC1), and one anti-inflammatory and insulin-sensitizing adipokine (Adipoq) (Figure 5A) and activated the ERK and AKT signaling pathways (Figure 5C)

Lastly, we examined cellular protrusions and adhesions as integrin-containing, multi-protein structures that form mechanical links between intracellular actin bundles and the extracellular substrate in many cell types

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