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doi:10.1046/j.1464-410x.2003.04370.x

Reasor, Hastings, and Ulrich 2006;Chatman et al

Upon tissue disruption, danger-associated molecular patterns (DAMPs) Such as extracellular ATP, high-mobility group box 1 (HMGB1), and uric acid crystals are released from damaged cells [26, 27], while PAMPs from the wound microbiome including lipopolysaccharide (LPS) from Gram-negative bacteria, lipoteichoic acid from Gram-positive bacteria, and bacterial DNA-are detected by pattern recognition receptors (PRRs) such as NLRP3, AIM2, or NLRC4 [28]