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Subsequently, each participant received one of four treatments by intraduodenal infusion over 2 min in a double-blind, randomised fashion: (1) 1000 mg metformin (PCCA, Australia) dissolved in 50 ml 0.9% saline (154 mmol/l NaCl) at t = 60 min and 50 ml 0.9% saline at t = 30 and 0 min [Met (60 min)]