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Previous evidence has shown that adenosine is one of the neuromodulators involved in the pathophysiology of migraine (218)

Fine RL, Manfredo Vieira S, Gilmore MS, Kriegel MA (2020) Mechanisms and consequences of gut commensal translocation in chronic diseases

It requires sterile technique, causes discomfort for needle-averse individuals, creates potential injection site reactions, and demands careful rotation to avoid tissue damage over extended protocols

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