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Whereas restless leg syndrome is associated with both an iron deficiency in the brain for genetically susceptible individuals and dopaminergic system dysfunction, potentially involving a presynaptic hyperdopaminergic state, in other patient populations

However, most tears, especially in the avascular (white) zone, require surgery for full recovery

This review critically synthesizes experimental, translational, and clinical data to examine whether vitamin D, myo-inositol, and melatonin, three widely used but often studied in isolation bioactives, can act synergistically as a mechanistically coherent bioactive cocktail in PCOS

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