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Patients who may not be appropriate candidates include: Individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Those with a history of severe hypersensitivity reactions to semaglutide Patients with a history of pancreatitis (relative contraindication requiring careful risk-benefit assessment) Pregnant women or those planning pregnancy (contraindicated for weight management

RNA levels were normalized to -actin levels, and changes in CT cycle values between groups were compared

The target proteins were detected using the BeyoECL Plus detection kit (Beyotime, P0018, Shanghai, China), with GAPDH serving as an internal control and the target proteins were analyzed using ImageJ software (1.48 v)

While GLP-1 medications are a powerful catalyst for weight loss, the clinical data is clear: medication alone often leads to significant muscle wasting and diminished physical function