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Although B complex vitamins are water-soluble and excess amounts are typically excreted in urine, large doses can lead to adverse effects

Oral NR (strongest human RCT base) Multiple RCTs (Martens 2018, Conze 2019, Dollerup 2018, Brakedal 2022) consistently raised blood NAD+ with favorable tolerability at doses up to 1,000 mg/day

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