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Toxicity/exposure ratios for birds, fish and aquatic invertebrates based on application rates of 2.5 kg a.i./ha of chlorothalonil to soybeans (worst case) Risk category LC 50 (mg/litre Estimated exposure Toxicity/exposure or mg/kg diet) (mg/litre or ratio (TER) c mg/kg diet) a,b Acute bird 4640 73.7-535.7 63.0-8.7 Acute fish (stream) 0.01 0.009-0.04 1.1-0.25 Acute fish (pond) 0.01 0.01 1.0 Acute aquatic invertebrate (stream) 0.07 0.009-0.04 7.8-1.8 Acute aquatic invertebrate (pond) 0.07 0.01 7.0 a Estimated environmental concentration in the terrestrial environment (for bird exposure) is based on the stated application rate and the assumption of deposition on short grass using the US EPA nomogram

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All authors contributed to the writing of this article, approved the submitted version, involved in developing the plan for the article, and in reviewing and editing the manuscript

New England Journal of Medicine Jastreboff AM, et al