Disclosures: Saleha Aziz: Nothing to Disclose, Arsalan Hamid: Nothing to Disclose, Michael Hall: Nothing to Disclose, Mark Pedersen: Nothing to Disclose, Jan Petrasek: Nothing to Disclose 2037 HEPATIC STELLATE CELL-DERIVED THBS2 PROMOTE INTRAHEPATIC INFLAMMATORY INFILTRATION BY REGULATING SPP1 SECRETION DURING LIVER FIBROGENESIS Hong Li 1 Ning Zhang 2 Wen Zhang 1 Wenyue Wu 1 Yameng Sun 1 Shuyan Chen 1 Qi Han 1 Xuzhen Yan 3 Aiting Yang 1 Hong You 1 Wei Chen 1 , 1 Beijing Friendship Hospital,Capital Medical University, 2 Beijing Friendship Hospital, Capital Medical University, 3 Beijing Friendship Hospital, Capital Mdeical University Background: Our previous study demonstrated that Thrombospondin-2 (THBS2) plays a critical role in hepatic stellate cells (HSCs) activation and the progression of liver fibrosis through TLR4-FAK/TGF- signaling
Jastreboff AM, Ryan DH, Bays HE, Ebeling PR, Mackowski MG, Philipose N, et al
The Strategy: Follow the "one-for-one" rule
One obvious advantage of the small molecule agonists in the replacement of peptide GLP-1 analogues is that they could be administered orally, thus avoiding the discomfort of subcutaneous injections and increasing the compliance of patients
