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A serious AE was defined as an AE resulting in any of the following: death, life-threatening experience, in-patient hospitalization or prolongation of existing hospitalization, a persistent or significant disability/incapacity or a congenital anomaly/birth defect, or important medical event that might not be immediately life-threatening or result in death or hospitalization but might jeopardize the patient or might require intervention to prevent one of the other outcomes listed in the definition above

The ratio of CP/CI-AMPAR expression covaried with the expression of NMDARs, forming a continuum from synapses with mostly CP-AMPARs and weaker and slower NMDAR-mediated components to synapses with mostly CI-AMPARs but a strong and fast NMDAR component (Bischofberger and Jonas, 2002

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The good news: most changes in sexual desire during weight loss are temporary and manageable