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Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death

10.1016/j.jpeds.2006.09.042 J Pediatr

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Despite its potential benefits, there are valid concerns about the use of L-carnitine supplementation in cancer patients