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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

The difference between 10mg and 15mg was relatively small (about 1 percentage point), which is why many people find their effective maintenance dose in the 7.5mg to 10mg range without needing to push to maximum