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It may also promote GLP-1 secretion, which activates hepatic Akt, leading to FOXO1 phosphorylation and further suppression of gluconeogenesis (39, 125, 126)

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As for individuals misusing GH for recreational and athletic performance-enhancing purposes, GH, IGF-I and insulin levels are increased suggesting that insulin sensitivity is worsened and iatrogenic acromegaly is induced, especially if used long-term