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Participants were randomly assigned 3:1 to receive AMG 133 or placebo

Additional preclinical proof of concept came from similar studies in rodent models of T2D and/or obesity wherein the combined activation of both GLP-1R and GIPR resulted in superior glucose-lowering and/or reduction in weight gain compared to the activation of either receptor alone [[78], [79], [80]]

What are the management and treatment options for patients on tirzepatide (a dual GIP and GLP-1 receptor agonist) who develop symptoms suggestive of pancreatitis?

This model was particularly helpful for rural patients with limited local provider access