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25 However, the specific contribution of the GIPR and GLP-1R to the pharmacological effects of dual incretin receptor agonism are currently undetermined

When total B12 levels are difficult to interpret, measurement of holotranscobalamin (active B12), methylmalonic acid (MMA) , or homocysteine can provide a clearer picture of functional B12 status, though availability and interpretation vary (for example, MMA rises in renal impairment)

Visser WR, Smith-Harrison LI, Krzastek SC