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Ibrance (palbociclib) Disease area(s): Oncology Manufacturer(s): Pfizer 2024 Sales (USD): $4.37 billion Why it sold so well: Pfizers Ibrance generated $4.37 billion in global revenue in 2024, maintaining its position as a leading therapy for hormone receptor-positive (HR+), HER2-negative metastatic breast cancer

However, traditional systemic drug delivery to the brain is limited by the BBB, requiring higher dosage or prolonged treatment schedules that can lead to suboptimal brain concentrations and potential systemic side effects

The peptide also increases integrin expression in basal keratinocytes at concentrations of 0.1-10 micromolar, enhancing p63 positivity, a transcription factor that maintains stem cell characteristics

10.1002/jcp.29232 J