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Several references use about 14 g fiber per 1,000 calories as a guideline, and JAMA also emphasizes adequate water intake

Figure 3 Targeted next-generation sequencing (NGS) using a customized hybrid-capture panel covering all coding regions as well as selected intronic and promoter regions of 130 genes [as described by Sahm et al

4 had pigmentation affecting the lower limbs and 4 had pigmentation affecting the upper limbs Of the 14 patients who discontinued the doxycycline, nine reported resolution of the pigment, four reported the hyperpigmentation did not resolve, and one case outcome was not described