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Gallbladder Removal (Cholecystectomy) Required in many moderate or severe cases

The documented doses, such as 0.01 to 1 mg/kg intravenously in animal models or 0.03 mg/kg intravenously in the clinical ileus study, are pure study parameters and serve to describe the state of research

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Acknowledgements We acknowledge the contributions of the clinical staff of the Intramural Research Program of the National Institute on Drug Abuse, and the Clinical Research Unit of Johns Hopkins Bayview Medical Center, as well as the University of Maryland, Baltimore, a member of the Graduate Partnership Program, National Institutes of Health (NIH)