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But what we wanted to understand is what theyre doing in the brain. Key findings GLP-1 drugs act not only on metabolic pathways but also on brain circuits linked to reward Researchers identified a pathway connecting the hindbrain, central amygdala and dopamine-producing neurons The drugs reduce not just hunger, but the desire for high-calorie, rewarding foods Findings may help explain both therapeutic benefits and side effects such as nausea or reduced pleasure Beyond appetite suppression GLP-1 receptor agonists were originally developed to treat Type 2 diabetes by improving insulin response, with weight loss emerging as a secondary benefit

While some drugs target transport proteins, the development of specific and efficient drugs remains a formidable challenge, particularly given the unique structural features of membrane proteins

It has been applied to several NDDs, for which monogenic cause is known

Cells 11(17):2726 Yang K, Zeng L, Yuan X et al (2022) The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components