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The exact minimum effective concentration that recapitulates our observed suppressive ILC2 phenotype in vivo , remains to be determined, and will likely rely on a complex grouping of factors that take into account systems with endogenous melatonin rhythms (such that were absent in our studies both in vitro and in vivo with BALBc mice)

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The two COP1 molecules interact with DET1 and Ube2e2 in a similar manner as described before, i.e., their WD40 domains bind to blade IV and blade V-VI of the DET1 subunit, respectively