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Endothelial dysfunction is characterized by reduced nitric oxide (NO) synthesis and/or bioavailability within peri-endothelial environment, where NO is responsible for maintenance of vascular tissue integrity 3

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Newer drugs, such as tirzepatide, a dual GLP-1, and GIP receptor agonist, are quickly gaining traction and demonstrating encouraging outcomes in clinical trials for weight management. Other popular diabetes medications include metformin, gliflozins (Farxiga, Jardiance), and sulfonylureas (Glucotrol, Amaryl)

Currently, 232 anti-obesity drugs are in development, with the most advanced utilizing GLP-1 combined with other hormones