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Centrally, GLP-1 promotes satiety through the activation of GLP-1 receptors in the hypothalamus and brainstem, which causes a reduction in food intake
Duration of Benefit The health benefits of GLP-1R agonists are most pronounced within the first year of treatment, with significant improvements in glycated hemoglobin (HbA1c), body mass index (BMI), and cardiovascular outcomes
Rapid weight loss is associated with an increased risk of gallstone formation
In my clinical practice, if patients want to stay on weekly therapy indefinitely, I dont stop them
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