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Currently, CRISPR is limited to in vitro and animal studies due to safety and ethical barriers, but advances in delivery vectors and base editing technologies may accelerate clinical translation (Inoue et al., 2023

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The research is strongest in soft-tissue repair and gastrointestinal protection models, with evidence showing benefit in tendon healing, ligament repair, muscle injury, wound healing, angiogenesis, inflammatory modulation, and gut mucosal protection

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