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To investigate whether the gut microbiome and its metabolites contribute to statin-associated glucose intolerance, we recruited 30 patients with atorvastatin and 10 controls, followed up for 16 weeks, and found a decreased abundance of the genus Clostridium in feces and altered serum and fecal bile acid profiles among patients with atorvastatin therapy

255 Methionine adenosyl-transferase 1 (MAT1) synthesizes SAM in the liver

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In previous large-scale clinical trials of GLP-1RAs, 15.2% ( n = 618) of AMPLITUDE-O and 6.1% ( n = 575) of Harmony Outcomes patients used SGLT2is at baseline [18, 20] (Table 1)