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Each step in fatty acid oxidation involves acyl-CoA derivatives, is catalyzed by separate enzymes, utilizes NAD + and FAD as coenzymes, and generates ATP

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While analyses restricted to participants with established cardiovascular disease yielded MACE results that were directionally consistent with the overall analysis, conclusions are limited because subgroup estimates were based on trial-level reporting rather than individual participant data, and included studies continued to differ in patient characteristics, definitions of established cardiovascular disease, background therapies, and trial era