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Retatrutide (LY3437943): complete guide to the first GLP-1R / GIP-R / GCGR triple agonist in metabolic research Retatrutide (Eli Lilly development code LY3437943) is the first synthetic peptide to combine agonism at three metabolic hormone receptors: the GLP-1 receptor (GLP-1R), the GIP receptor (GIP-R), and the glucagon receptor (GCGR)