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Improved Metabolic Function Lipedema is often associated with: Insulin resistance Impaired fat metabolism Mitochondrial dysfunction Emerging research suggests that lipedematous adipose tissue is metabolically inflexible, with reduced capacity for lipid mobilization and altered mitochondrial activity (Viana et al., 2025)

Kosiborod MN, Petrie MC, Borlaug BA, Butler J, Davies MJ, Hovingh GK, Kitzman DW, Moller DV, Treppendahl MB, Verma S, et al

This is because it increases the risk of lactic acidosis, a serious side effect of metformin

The test solution should be transferred with a sterile syringe to avoid external contamination