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Elevated phosphorylation levels of AMPK were noted in the liver, muscle tissue, and adipocytes of mice subjected to insulin resistance from high-fat diets and streptozotocin (STZ)-induced diabetes models (Masahito et al., 2010

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Many of the newer agents in T2D, particularly SGLT2 inhibitors and GLP-1 receptor agonists, are being highlighted for their cardiovascular benefits, which is an important consideration given the risk of heart disease associated with T2D