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SURMOUNT-2 (NCT04657003) Study Title: "Tirzepatide Once Weekly for the Treatment of Obesity in People With Type 2 Diabetes" Status: Completed Phase: Phase 3 Enrollment: 938 participants Study Period: 2020-2022 Design: Randomized, double-blind, placebo-controlled Duration: 72 weeks Intervention: Tirzepatide 10/15 mg SC weekly vs

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Syringe Units = Volume to Draw (mL) 100 = 0.25 mL 100 = 25 units TB-500 Dosing Profile (10 mg Vial / 1 mL BAC Water) 2.5 mg Dose: Draw 25 units (0.25 mL)

Robert Considine - metabolic research) Eli Lilly and Company (trial sponsor and developer) Clinical Evidence Summary: Tirzepatide's dual GIP/GLP-1 receptor agonism has produced weight loss (up to 22.5% mean reduction) and HbA1c improvements (up to 2.6% reduction) that exceed all currently available GLP-1 RA monotherapies