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Sterile water lacks the antimicrobial preservative (0.9% benzyl alcohol) that prevents bacterial contamination in multi-dose vials, so reconstituting with sterile water limits use to single-dose administration the solution must be used immediately and any remainder discarded

A viscous or gel-like structure forms because of the gradual release of an organic solvent, and this gel collapses at a critical stage in the process, disrupting certain inverted micelles