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OPG is a soluble circulating decoy receptor for RANKL and is secreted by cells and binds to the extracellular structural domain of RANKL, preventing RANKL from osteoclast binding ( The role of MOTS-c in osteoclasts is closely related to the regulation of bone metabolism by OPG/RANKL

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Both preclinical and clinical studies have consistently demonstrated significant body weight reduction (significant loss of 240320 calories/daily resulting in average weight loss of 24 kg during the first 24 weeks) after their administration

Empowering individuals with diabetes in self-care by educating them about diet and lifestyle factors enhances self-efficacy and reduces feelings of helplessness, which can also alleviate anxiety and depressive symptoms [228]