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Pravat Mandal has identified a key finding patients with Alzheimers, Parkinsons disease, and those exposed to repetitive head impacts (such as former NFL players, combat warriors, and Navy SEALs) often show a deficiency in glutathione, the brains primary antioxidant
Along this line, Cbl shortcoming can cause malformation of the myelin sheath, which may mirror the symptoms of multiple sclerosis
Nordlund et al., 2006a
These interaction patterns indicate pathway-level connectivity rather than isolated metabolite changes and support the involvement of amino acid and polyamine metabolism in ASD-associated metabolic alterations
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