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Ethics statement The animal study was reviewed and approved by the Ethics Committee of Third Xiangya Hospital, Central South University

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In HUVECs treated for 1 h with different concentrations (200, 400, 600, 800, and 1000 M) of H 2 O 2 , cells showed reduced cell viability, migration, and angiogenic capacity, along with a significant increase in senescence markers (-galactosidase) [116]