Adjunctive topical agents may be applied during treatment depending on clinical judgement
Among them, preobesity/obesity, MASLD and some coexisting hypertension, closely related to poor lifestyle, are independent risk factors for the development of cardiovascular-kidney-metabolic syndrome and T2D, 2 indicating their preventable characteristic
Moreover, when mice were pre-treated with vehicle or L2-Cmu (20 mg/kg) by intraperitoneal (i.p.) injection, and then challenged with an intravenous (i.v.) bolus of saline or 5 g IGF-1, L2-Cmu was able to modulate IGF-1R activation in vivo, as demonstrated by a near complete inhibition of IGF-1R phosphorylation in lung and ~70% inhibition in heart (Fig
However, if you have underlying issues like poor sleep hygiene, chronic stress, nutritional deficiencies, or suboptimal thyroid/sex hormone levels, addressing these first will likely yield better results, even without peptides