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Research on Alzheimers disease models has demonstrated that hydrogen therapy can reduce cell apoptosis by modulating key apoptotic regulators such as Bax and caspase-3, thereby promoting neuronal survival ( In a neonatal rat hypoxicischemic brain injury (HIBI) model, hydrogen significantly reduced the Bax/Bcl-2 ratio by up-regulating the expression of the anti-apoptotic protein Bcl-2, while down-regulating the expression of the pro-apoptotic protein Bax and the apoptosis-executing enzyme caspase-3, leading to a reduction in apoptosis (Wang et al., 2020)

Based on the stubbornness and skin type, dermatologists may suggest combinational treatments for better results