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These maternal conditions, particularly inflammation or elevated body temperature, are known to affect fetal brain development

The "GHK" designation comes from the single-letter amino acid codes: G = Glycine H = Histidine K = Lysine (using K because L was already assigned to Leucine) Natural Occurrence and Age-Related Decline In human plasma, GHK-CU levels start at approximately 200 ng/mL at age 20

Neuroinflammation 9 (1), 113

Multiple early-phase clinical programs have evaluated agents modulating these mechanisms, such as CCR2/CCL2 blockade (emapaticap pegol, CCX140-B) (Zhou et al., 2025b), IL-6 neutralization (ziltivekimab), and anti-fibrotic candidates like pirfenidone or ASK1 inhibition (selonsertib) (Petrovic et al., 2025) (Figure 6)