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This proportion of super responders people that lose at least 20 percent of their starting weight is similar to whats seen when people take injected GLP-1 medications, says Jody Dushay, MD, an endocrinologist at Beth Israel Deaconess Medical Center and an assistant professor at Harvard Medical School in Boston

Additionally, SCFAs upregulate tight junction proteins, enhancing intestinal barrier function and preventing endotoxin translocation, which would otherwise provoke systemic inflammation and exacerbate kidney injury (82, 83)

Back Trapp, S, Brierley, DI (29 July 2021) 'Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment' British Journal of Pharmacology

Numerous studies on neurodegenerative diseases have shown that NRF2 stabilizes under chronic oxidative stress and inflammation but it still fails to increase the antioxidant genetic program to the level needed to fight against the ongoing oxidative stress