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Description

Mice lacking PGC-1 in adipose tissues reveal a dissociation between mitochondrial dysfunction and insulin resistance

Insulin resistance and hyperinsulinaemia stimulate the production of androgens (male hormones present in both sexes) and reduce levels of sex hormone-binding globulin (SHBG)

To develop REPAIR, the Cas13b ortholog was mutated to be catalytically dead Cas13b (dCas13b) and fused with the adenosine deaminase acting on RNA 2 (ADAR2) enzymeallowing for the replacement of adenosine (A) residues to inosine (I) residues on mRNA transcripts