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4.3 Comparative safety profiles of biomaterial and systemic therapeutic approaches Biomaterial delivery platforms can markedly reduce the off-target toxicities of systemic immunotherapies by concentrating antigen or immunomodulatory cargo in tolerogenic tissues or the diseased microenvironment, enabling lower total doses, controlled release, and biomimetic presentation that better recapitulates apoptotic-cell-driven tolerance (206, 207)

While some individuals have reported positive outcomes, including weight management and energy improvements, others might not experience the same level of benefits

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