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2022: An analysis called Gastrointestinal adverse events associated with semaglutide: A pharmacovigilance study based on FDA adverse event reporting system describes post-marketing adverse events for the first three years that semaglutide (Ozempic) was on the market

Quick Answer: Weight gain on tirzepatide can occur due to fluid retention, metabolic adaptation, inadequate dosing, medication interactions, lifestyle factors, or underlying medical conditions that counteract the medication's appetite-suppressing effects

GLP-1 agonists may also help the heart pump better , improving blood flow and decreasing the risk of heart-related health problems