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Pharmacokinetics: Data indicate a linear pharmacokinetic profile with a short half-life ( 1000mcg/day) have been anecdotally associated with increased chances of headaches, fatigue, or water retention, and may lead to diminishing returns, suggesting a bell-shaped dose-response curve

Our guides on whether you can take phentermine and semaglutide together and the comparison of phentermine vs semaglutide address two of the most common combination questions

Some patients actually report improved energy once the initial adjustment period passes, as described in our guide on semaglutide and energy

Worsening of diabetic retinopathy has been observed primarily with semaglutide during rapid glycemic improvement, particularly in patients with pre-existing retinopathy